Kavita Dubey
Thapar University, Patiala
Title: Quantification of breast cancerous tissue using high resolution full-field optical coherence tomography
Biography
Biography: Kavita Dubey
Abstract
Conventional optical coherence tomography system is based on point-by-point scanning which consumes more time for large volume acquisition and also suffers poor resolution (10 µm). In this study, we used low coherence full field optical coherence tomography (FFOCT) system based on Mirau interferometer, which provide 3D micron level resolution. The system is used for the quantification of normal and malignant breast tissue. Transverse cross-section (en-face, or XY) images can be obtained in real time with better than 2-microm axial (Z) resolution and 1.0-microm transverse (XY) resolution. 10 tissue samples (5 normal, 5 malignant) were imaged with the FFOCT system and six features were extracted by analyzing the 40 FFOCT images, based on the differences in the morphology of the normal and malignant tissue samples. A k-nearest neighbor (k-nn) classifier was trained using 24 images, and sensitivity of 91.6 % and specificity of 83.33 % was obtained. The pathological structures were distinguished from the normal structure. The principle, experimental details and results for breast cancer analysis, and will be later presented.